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IP and Publication

Intellectual property

Today, IMSTAR holds 13 patents (6 issued, 7 pending), 70 copyrights and exclusive licenses, as well as proprietary opto electronic and robotic devices, which allows it to offer unique automated solutions based on operator-independent tests in the fields of automated quantitative imaging for cellular analysis and screening in the entire application spectrum in Life Sciences and in vitro diagnostics.

These tests include:

  • HTS HCS for Toxicology and Drug Discovery (compounds, cells & tissue screening).
  • Detection of tumor cells in micro biopsies.
  • Diagnostics of Down’s syndrome (Trisomy 21).
  • Predictive diagnostic (Cervix cancer mass screening)
  • DNA microarrays for assay development (quantitation & kinetics) and diagnostics.
  • Cell-on-chip assays for multiplex phenotype, siRNA (primary and secondary) screening at sub-cellular level.

Selected Publications

  1. Lemaire F., Mandon CA., Reboud J., Papine A., Angulo J., Pointu H., Diaz-Latoud C., Lajaunie C., Arrigo AP., Schaack B. Toxicity assays in nanodrops combining bioassay and morphometric endpoints.PloS ONE, 2007 Jan17;2:e163
  2. Sallette J., Al Sayed N., Laboureau J., Adem C., Soussaline F., Breton L. Neuropeptide Y may be involved in human lip keratinocytes modulation. ESDR Congress, September 2006, Paris.
  3. Soussaline F., Decordier I., Sallette J., Plas G., Papine A., Roesems S., Tatarinova E., Kirsch-Volders M. A new integrated quantitative imaging method for automated micronuclei detection and scoring using Pathfinder™ Image cytometer. EEMS Congress, July 2006, Prague.
  4. Sallette J., Papine A., Belaidi J-F., Marrot L., Meunier J-R., Soussaline F. A fully automated high-content-screenning imaging system for comet assay. EEMS Congress, July 2006, Prague.
  5. Tourniaire G A., Sallette J., Bradley M. High Throughput Screening of Biocompatible Polymers. MedChem Europe 2006, 21-22 February 2006, Prague.
  6. Soussaline F., Truong K., Homsy C., Papine A., Hammou J-C., El Saëd N. Cervix cancer diagnostic and Breast cancer Her-2neu staging using automated imaging system on specific monolayer for non-operator dependant accurate quantification. In Proc. of WABT International conference on “Woman Health”. UNESCO March 7th –9th, 2005.
  7. Laurent C., Pouget J-P., Voisin P. Modulation of DNA damage by pentoxifylline and α-tocopherol in skin fibroblasts exposed to gamma-rays, Radiat Res 2005 Jul;164(1):63-72.
  8. Lorge E., Truong K., Homsy C., Tatarinova E., Soussaline F., Delongeas J-L., Claude N. Detection and scoring of micronuclei in genotoxicity: A validation study using PATHFINDERTM, an automated imaging system, applied to the in vitro micronucleus assay on L5178Y cells. Annual Meeting of SFGT Mutagenese, July 2004, Toulouse France.
  9. Truong K., Gibaud A., Zalcman G., Guilly M-N., Antoine M., Commo F., Fouquet C., Cadranel J., Soussi T., Dutrillaux B., Malfoy B. Quantitative fish determination of chromosome 3 arm imbalances in lung tumors by automated image cytometry.
    Med Sci Monit, 2004; 10(11) : BR426-432.
  10. Baghdoyan S., Roupioz Y., Pitaval A., Castel D., Khomyakova E., Papine A., Soussaline F., Gidrol X. Quantitative analysis of highly parallel transfection in cell microarrays. Nucleic Acids Research, 2004, vol. 32, N°. 9 e77.
  11. Khomyakova E.B., Dreval E.V., Tran-Dang M., Potier MC., Soussaline F. Innovative instrumentation for Microarray scanning and analysis : Application for characterization of oligonucleotide duplexes behavior. Cellular and Molecular Biology. 50 (3), 217-224, 2004.
  12. Khomyakova E., Dreval E-V., Durand M-C., Dauphinot L., Rossier J., Potier M-C., Soussaline F. Optimisation of gene expression experiments using on-chip real-time reactions. In Proceedings of International Society of Neurochemistry Conference (ISN), 13-16 May 2004, Avignon, France
  13. Truong K., Soussaline F., Gibaud A., Dupont J-M., Guilly M-N., Dutrillaux B., Malfoy B. Rapid prenatal diagnosis of Down syndrome using quantitative fluorescence in situ hybridization on interphase nuclei.In Proceedings of XIV Worshop on Fetal Cells and Fetal DNA, 17-18 April 2004, University of Jena, Germany.
  14. Pouget J-P., Laurent C., Delbos M., Benderitter M., Clairand I., Trompier F., Stephanazzi J., Carsin H., Lambert F., Voisin P., Gourmelon P. PCC-FISH in skin fibroblasts for local dose assessment: biodosimetric analysis of a victim of the Georgian radiological accident, Radiat Res. 2004 Oct;162(4):365-76
  15. Grégoire E., Garcia O., Buard V., Laurent C., Roy L., Voisin P. Evaluation of DNA damage on comet assay using computerized image analysis and visual scoring, ISAC XXII International Congress, 2004, Montpellier, France.
  16. Bedossa P., Dargere D., Paradis S-V. Sampling variability of liver fibrosis in chronic hepatitis C. Hepatology 2003 December, vol 38:1449-1457, N°6

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IMSTAR S.A.
60 Rue Notre Dame-des-Champs
75006 Paris, France
Tel: +33 (0) 1 42 34 93 70
Fax: +33 (0)1 46 34 51 57
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